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Erythrocyte fragility refers to the propensity of erythrocytes (red blood cells, RBC) to hemolyse (rupture) under stress. It can be thought of as the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to stress (typically physical stress, and most commonly osmotic and/or mechanical stress). Depending on the application as well as the kind of fragility involved, the amount of stress applied and/or the significance of the resultant hemolysis may vary. When multiple levels of stress are applied to a given population/sample of cells, a ''fragility profile'' can be obtained by measuring the relative or absolute extent of hemolysis existing at each such level,〔http://spherocytosis.info/2012/01/osmotic-fragility-test/〕 in addition to finding one or more single-number ''indexes''〔(【引用サイトリンク】title=The Mechanical Fragility of the Red Cell in Patients with Lead Poisoning )〕 (either measured directly or interpolated) associated with particular respective levels of hemolysis and/or corresponding stress. Fragility testing can be useful to assess cells' ability (or lack thereof) to withstand sustained or repeated stress. Moreover, it can be used to assess how fragility itself varies under different or changing environmental or stress conditions, during or prior to the inducement of the hemolysis. Low fragility is often termed "stability," though technically stability refers to cells' resistance to ''both'' stress-induced lysis ''and'' spontaneous auto-lysis. ==Erythrocyte ''osmotic'' fragility== Osmotic fragility (OF) refers to the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to osmotic stress by being placed in a hypotonic solution. Osmotic fragility is affected by various factors, including membrane composition and integrity as well as the cells' sizes or surface-area-to-volume ratios. The osmotic fragility test is common in hematology, and is often performed to aid with diagnosis of diseases associated with RBC membrane abnormalities. Some diseases linked to ''increased'' OF include hereditary spherocytosis and hypernatremia, while some linked to ''decreased'' OF include chronic liver disease, iron deficiency anemia, thalassemia, hyponatremia, polycythemia vera, and sickle cell anemia after splenectomy.〔(【引用サイトリンク】title=Osmotic Fragility is a test for hereditary spherocytosis - ClinLab Navigator )〕 New approaches to testing OF are under development to better facilitate its use in disease diagnosis and screening, such as by utilizing microfluidic devices along with cell counting.〔(【引用サイトリンク】title=A microfluidic platform for osmotic fragility test of red blood cells - RSC Advances (RSC Publishing) )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Erythrocyte fragility」の詳細全文を読む スポンサード リンク
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